Supreme Multi 240 capsules

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Amount Per Serving

% Daily Value

Vitamin A (75% as natural beta-carotene and 25% as retinyl palmitate)

1,120 mcg

124%

Vitamin C (as sodium ascorbate, potassium ascorbate, zinc ascorbate, and calcium ascorbate)

125 mg

139%

Vitamin D3 (cholecalciferol)

2.5 mcg (100 IU)

13%

Vitamin E (as d-alpha tocopheryl succinate)

67 mg

44%

Thiamin (as thiamine mononitrate)

10 mg

833%

Riboflavin (as riboflavin 5’-phosphate sodium)

10 mg

769%

Niacin (as niacinamide and niacin)

32 mg

200%

Vitamin B6 (as pyridoxal 5’-phosphate)

10 mg

588%

Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)S1

340 mcg DFE

85%

Vitamin B12 (as methylcobalamin)

250 mcg

10,417%

Biotin

500 mcg

1,667%

Pantothenic Acid (as d-calcium pantothenate)

100 mg

2000%

Choline (as choline dihydrogen citrate)

18 mg

3%

Calcium (as di-calcium malateS2, d-calcium pantothenate, and calcium ascorbate)

50 mg

4%

Iodine (as potassium iodide)

50 mcg

33%

Magnesium (as di-magnesium malate)S2

50 mg

12%

Zinc (as zinc bisglycinate chelate)S2

6.5 mg

59%

** Daily Value (DV) not established.

Capsule (hypromellose and water), microcrystalline cellulose, ascorbyl palmitate, silica, medium-chain triglyceride oil, and mixed tocopherols.

Take two capsules twice daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Adequate nourishment is the foundation for overall health and wellness, and good nutrition typically translates into a stronger immune system and better health. The human body uses dietary proteins, fats, and carbohydrates, known as macronutrients, to provide the energy (calories) needed to fuel physiological functions. Vitamins and minerals, known as micronutrients, are needed in much smaller quantities. Unlike their macro counterparts, micronutrients don’t give you energy, but they do participate in converting food to energy; building and repairing tissues and DNA; manufacturing neurotransmitters, hormones, and other modulators in the body; breaking down and detoxifying xenobiotics and medications; and maintaining growth, reproduction, and health.*[1-3]

According to the Dietary Guidelines for Americans 2020-2025 (DGA) and additional data from the USDA and other agencies and organizations, the American diet lacks micronutrients.[4-6] Mass food production, storage techniques, poor food choices, and nutrient-depleting preparation methods may be contributing to this deficit. Furthermore, the percent daily values (%DV) for micronutrients are based on the minimum amount needed to meet the basic need of a healthy person of a specific age and gender group. The %DV is not always indicative of the amount needed for optimal functioning of all individuals, especially those who are chronically ill.*[3,5,7]

When considering where American diets fall short in nutrients, the DGA shows that low intakes of potassium, dietary fiber, calcium, and vitamin D are a public health concern.[4] Other nutrients that have notably low intakes or require increased intake subsequent to life stage include vitamins A, B6, B12, C, E, and folate; the mineral magnesium; and choline.[4,8,9] Data from the National Health and Nutrition Examination Surveys (NHANES) suggest a pervasive deficiency in A, C, D, E, and zinc—nutrients linked to immune health.[6] Inadequate intake of most of these nutrients is attributable to an overall unhealthy eating pattern due to low intakes of nutrient-rich foods such as vegetables, fruits, whole grains, and dairy that contain these nutrients.[4] In cases when food is not enough for an individual to get adequate micronutrients, multivitamin/mineral supplements are recognized as being of value to help fill dietary nutritional shortfalls.*[2,6,7,10-12]

Supreme Multi is designed to meet the foundational nutrition needs for a variety of protocols and life stages. This formula provides: Balanced Profile Vitamins and minerals work cooperatively when present in sufficient amounts. However, imbalances between micronutrients can disrupt this synergistic relationship, possibly leading to instances of competitive intestinal absorption or displacement at the metabolic/cellular level, which can produce relative excesses and insufficiencies. For this reason, Supreme Multi features a balanced nutrient profile that includes calcium and magnesium, zinc and copper, vitamins C and E, bioactive folate, vitamin B12, B vitamin complex, beta-carotene, and trace elements.* Bioavailability Nutrient Forms The micronutrients are provided in bioactive forms so that they can be adequately absorbed and utilized. Supreme Multi contains an iron-free complement of Albion® patented mineral chelates and complexes. Albion is a recognized world leader in mineral amino acid chelate nutrition and manufactures highly bioavailable nutritional mineral forms that are validated by third-party research and clinical studies.  Supreme Multi also contains natural vitamin E, clinically shown to be more bioavailable than synthetic dl-alpha-tocopherol, as well as mixed tocopherols to approximate how much vitamin E an individual might gain when consuming healthful foods.[13,14] The folate source in this formulation is methyltetrahydrofolate (5-MTHF)—the most bioactive form of folate[15]—in the form of Quatrefolic®, which has greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF. Supplementing with bioactive 5-MTHF facilitates the bypassing of steps in folate metabolism. This may be especially beneficial to individuals with genetic variations in folate metabolism.[16,17] Vitamins B2, B6, and B12 are provided in metabolically active forms.* Support for Energy Production and Stress Response  Supreme Multi provides generous levels of B vitamins which serve as prime coenzymes in glycolysis and oxidative phosphorylation and as cofactors in amino acid and lipid metabolism.[18-20] Sufficient levels of the B vitamins are critical for energy production and cell growth and division, and they have many other essential roles in the body, including support for nervous system function.[21]  The balanced presence of B vitamins is essential to their cooperative functioning and excellent for individuals with stressful lifestyles.* Antioxidant Protection Vitamins E and C, selenium, zinc, beta-carotene, and trace elements provide broad-spectrum antioxidant activity.[22,23] Their combined presence supports their ability to regenerate each other and maintain consistent levels of antioxidant activity both intra- and extracellularly.*

Detoxification Support Xenobiotics, including environmental pollutants and medications, must undergo biotransformation into molecules that can be easily excreted from the body. Detoxification of xenobiotics is a complex process that requires micronutrients, phytonutrients, energy, and adequate antioxidant support for safe and effective completion.[23-25] There are significant levels of bioavailable riboflavin, niacin, folate, and B12 present in Supreme Multi to support phase I detoxification. Beta-carotene, vitamin C, tocopherols, selenium, copper, zinc, and manganese are present to support tissues when reactive intermediates are formed between phase I and phase II detoxification.* Supreme Multi offers foundational multivitamin and mineral support designed to compensate for dietary nutritional shortfalls and nourish optimal wellness. This formulation is iron-free for individuals who typically do not need to supplement their diet with iron, including most men and post-menopausal women.*

1. Ames BN. Arch Biochem Biophys. 2004;423(1):227-234. doi:10.1016/j. abb.2003.11.002

2. Block G, Jensen CD, Norkus EP, et al. Nutr J. 2007;6:30. doi:10.1186/1475-2891-6- 30

3. Fletcher RH, Fairfield KM. JAMA. 2002;287(23):3127-3129. doi:10.1001/jama.287.23.3127

4. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th ed. December 2020. https://www.dietaryguidelines.gov/sites/default/files/2020-12/Dietary_Guidelines_for_Americans_2020-2025.pdf

5. Blumberg JB, Bailey RL, Sesso HD, et al. Nutrients. 2018;10(2):248. doi:10.3390/nu10020248

6. Reider CA, Chung RY, Devarshi PP, et al. Nutrients. 2020;12(6):1735. doi:10.3390/nu12061735

7. Multivitamin/Mineral Supplements Fact Sheet. National Institutes of Health. Updated October 12, 2021. Accessed November 29, 2021. https://ods.od.nih.gov/ factsheets/MVMS-HealthProfessional/?print=1

8. Bird JK, Murphy RA, Ciappio ED, et al. Nutrients. 2017;9(7):655. doi:10.3390/nu9070655

9. Multivitamin/Mineral (MVM) Inclusion in the Supplemental Nutrition Assistance Program (SNAP). Council for Responsible Nutrition; 2017. Accessed December 6, 2021. https://www.crnusa.org/multivitamin-mineral-mvm-inclusion-supplementalnutrition-assistance-program-snap

10. Blumberg JB, Frei BB, Fulgoni VL, et al. Nutrients. 2017;9(8):849. doi:10.3390/nu9080849

11. Blumberg JB, Cena H, Barr SI, et al. Clin Ther. 2018;40(4):640-657. doi:10.1016/j.clinthera.2018.02.014

12. Marra MV, Bailey RL. Position of the Academy of Nutrition and Dietetics: micronutrient supplementation. J Acad Nutr Diet. 2018;118(11):2162-2173. doi:10.1016/j.jand.2018.07.022

13. Kiyose C, Muramatsu R, Kameyama Y, et al. Am J Clin Nutr. 1997;65(3):785-789.doi:10.1093/ajcn/65.3.785

14. Burton GW, Traber MG, Acuff RV, et al. Am J Clin Nutr. 1998;67(4):669-684.doi:10.1093/ajcn/67.4.669

15. Venn BJ, Green TJ, Moser R, et al. Am J Clin Nutr. 2003;77(3):658-662. doi:10.1093/ajcn/77.3.658

16. Prinz-Langenohl R, Brämswig S, Tobolski O, et al. Br J Pharmacol. 2009;158(8):2014-2021. doi:10.1111/j.1476-5381.2009.00492.x

17. Lamers Y, Prinz-Langenohl R, Brämswig S, et al. Am J Clin Nutr. 2006;84(1):156-161.doi:10.1093/ajcn/84.1.156

18. Calderón-Ospina CA, Nava-Mesa MO. CNS Neurosci Ther. 2020;26(1):5-13.doi:10.1111/cns.13207

19. Kennedy DO. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068

20. Depeint F, Bruce WR, Shangari N, et al. Chem Biol Interact. 2006;163(1-2):94-112.doi:10.1016/j.cbi.2006.04.014

21. B Vitamins. National Library of Medicine. MedlinePlus. Last reviewed September 23, 2021. Accessed December 2, 2021. https://medlineplus.gov/bvitamins.

22. Jayedi A, Rashidy-Pour A, Parohan M, et al. Adv Nutr. 2018;1;9(6):701-716.doi:10.1093/advances/nmy040

23. Doyle ME, Pariza MW. In: Kotsonis FN, Mackey MA, eds. Nutritional Toxicology. 2nd ed. Taylor & Francis; 2002:1-30. https://doi.org/10.1201/9781420025088

24. Liska DJ. Altern Med Rev. 1998;3(3):187-98.

25. Hodges RE, Minich DM. J Nutr Metab. 2015;2015:760689. doi:10.1155/2015/760689