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Dutch Plus

Dutch Plus

Regular price $650.00
Regular price Sale price $650.00
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Description

The DUTCH Plus® takes hormone testing to a new level. In addition to sex hormones and their metabolites, the DUTCH Complete™ looks at the overall diurnal pattern of free cortisol, and the total and distribution of cortisol metabolites. The DUTCH Plus® adds the Cortisol Awakening Response (CAR) to bring another important piece of the HPA axis into focus.

The DUTCH Plus® is an advanced hormone testing profile that takes hormone testing to a new level. In addition to sex hormones and their metabolites, the DUTCH Plus® provides a comprehensive assessment of adrenal function by measuring the overall diurnal pattern of free cortisol and the total and distribution of cortisol metabolites.

This test also includes the Cortisol Awakening Response (CAR), which measures the cortisol levels in the morning shortly after waking up. This provides important information about the body's natural cortisol rhythm and can help identify any imbalances or abnormalities that may be contributing to symptoms such as fatigue, weight gain, and hormonal imbalances.

The DUTCH Plus® is a non-invasive test that can be performed from the comfort of your own home, with urine samples collected at specific times throughout the day. It is suitable for both men and women and can be used to evaluate a wide range of hormonal issues, including fertility, menopause, and adrenal dysfunction.

Once the samples are processed, the test provides a clear and easy-to-understand report that summarizes the results and provides recommendations for addressing any imbalances or abnormalities. The report includes personalized recommendations for diet, lifestyle, and supplements that can support hormone balance and overall health and wellbeing.

Overall, the DUTCH Plus® is a valuable tool for evaluating hormone balance and adrenal function and identifying any imbalances or abnormalities that may be contributing to symptoms. It provides a comprehensive assessment of hormonal health and can provide important information to guide treatment decisions and support overall hormonal balance and wellbeing.

Supplement Facts

Kit Includes

- Easy-to-follow Directions and Requisition Form

- (4) Urine Collection Strips and (6) Salivette™ Saliva Collection Tubes

- Resealable Plastic Bag

- Sealable Return Envelope

Results Include

- Analysis of 35 different hormones: estrogen, progesterone, testosterone, DHEA-S, and cortisol along with their metabolites, plus the cortisol awakening response (CAR)

- Graphical representation of results and embedded video tutorials to assist in the hormone assessment to share with your medical provider

- DUTCH OATs: Melatonin (6OHMS), 8-Hydroxy-2-deoxyguanosine (8-OHdG), and six organic acid tests (OATs) including markers for vitamin B12 (methylmalonate), vitamin B6 (xanthurenate), kynurenate, glutathione (pyroglutamate), dopamine (homovanillate), norepinephrine/epinephrine (vanilmandelate).

See the Dutch Plus info sheet here.
See a sample female test here.
See a sample male test here.
See the Dutch Plus Collection Instructions here.
See an explanation video here.

What Doctor Birch Says

This is the kit we use most often in our office to monitor hormones, metabolites, and important nutrients involved in the hormonal pathways for our female patients. This is an excellent test to perform at least twice per year in order to monitor your need for bioidential hormone replacement, as well as to monitor how your current dosages are working for you. Feel free to purchase this kit and book a consultation with us to start or continue your journey with us. Wishing you all the best.



RESTRICTIONS APPLY FOR ORDERING LAB TESTS IN THE STATES OF NEW YORK, MARYLAND AND RHODE ISLAND. If you live in one of these states, please give us a call at 503.687.2050 for more information.

PRICES ARE LISTING IN USD. INTERNATIONAL AND DOMESTIC ORDERS ARE ACCEPTED.

Return Policies

- Return policy for a refund is one year from the date of purchase.

- The kit must be returned to Purety Clinic before any refunds can be issued.

- Shipping fees are non-refundable.

- There is a $25 re-stocking fee.

Why Use It?

The DUTCH Plus® takes hormone testing to a whole new level. In addition to sex hormones and their metabolites, the DUTCH Complete™ looks at the overall diurnal pattern of free cortisol, and the total and distribution of cortisol metabolites. The DUTCH Plus® adds the Cortisol Awakening Response (CAR) to bring another important piece of the HPA-axis into focus. 

What is the Cortisol Awakening Response and how do we test for it?

When we open our eyes upon waking, cortisol levels naturally begin to rise by an average of 50%. 30 minutes after waking, cortisol levels will still show this sharp increase. By 60 minutes after waking, cortisol levels have peaked and begin to decline. Measuring this rise and fall of cortisol levels at waking can be used as a “mini stress test”. Research shows that the size of this increase correlates with HPA Axis function, even if the sample measurements are all within range. A quick saturation of saliva swabs upon waking, and at 30 and 60 minutes after waking, provide what is required to assess a patient’s Cortisol Awakening Response.

A low or blunted Cortisol Awakening Response

This can be a result of an underactive HPA Axis, excessive psychological burnout, seasonal affective disorder
(SAD), sleep apnea or poor sleep in general, PTSD, chronic fatigue, and/or chronic pain. A decreased CAR has also been associated with systemic hypertension, functional GI diseases, postpartum depression, and autoimmune diseases.

An elevated Cortisol Awakening Response

This can be a result of an over-reactive HPA Axis, ongoing job-related stress (anticipatory stress for the day), glycemic dysregulation, pain (i.e. waking with painful joints or a migraine), and general depression (not SAD). A recent study showed that neither the waking nor post-waking cortisol results correlated to Major Depressive Disorder, but the CAR calculation (the change between the first two samples) did. This measurement of the response to waking has independent clinical value showing dysfunction that may be hidden by current testing options.

When compared with others

Even though a patient may have “normal” free cortisol levels throughout the day, that doesn’t always mean everything is functioning properly. The graph below shows two good examples. A blunted or exaggerated Cortisol Awakening Response (CAR) can appear, even when single samples return “normal” results. The HPA axis might not be appropriately responding when faced with a stressor, even when cortisol levels are fluctuating nicely throughout the day. The “stress” of waking allows us to test the HPA axis in a way that has been independently correlated to clinical outcomes and cannot be assessed byother cortisol tests on the market.

When compared with others bottom

A true CAR assessmentrequires salivary samples to be collected at the moment of waking, and twice more, at 30 minutes after waking and 60 minutes after waking. These specifically timed collections are difficult and impractical with urine and traditional salivary options. The DUTCH Plus®uses specialty, FDA-approved, and patented collection devices called Salivettes™. Salivettes™ are specifically made for testing cortisol when timing needs to be precise and are used in nearly all of the published CAR studies. The small synthetic cotton swab can be quickly saturated with saliva, providing a very fast and simple collection. Unfortunately for labs using saliva to test reproductive hormones, they are not a viable option as the swabs cannot be used when testing progesterone. The DUTCH Plus® offers the most accurate salivary cortisol sampling with Salivette™ collection and analysis using LC-MS/ MS. An unparalleled clinical tool is created when combining salivary cortisol with the extensive urine metabolites from DUTCH.

They are high-quality and worth the money. The store also offered free shipping at that price so that's a plus!” “I recently purchased the Anti Aging Gel and serum from puretyclinic, and I couldn't be happier with my online shopping experience. Their website was user-friendly, making it easy to find the perfect item.

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