Supreme CoQ10

--

Amount Per Serving

%Daily Value

Calories

5

**

Total Fat

0.5 g

1%†

Fish Oil ConcentrateS1

500mg

**

Total Omega-3 Fatty Acids

348 mg

**

EPA (eicosapentaenoic acid)

230 mg

**

DHA (docosahexaenoic acid)

100 mg

**

Coenzyme Q10 (as ubiquinone)S2

100 mg

**

† Percent Daily Values are based on a 2,000 calorie diet.

† Percent Daily Values are based on a 2,000 calorie diet.
** Daily Value not established.

Softgel (bovine gelatin, glycerin, purified water, roasted
carob powder), yellow beeswax, and mixed natural tocopherols.

Take one softgel twice per day, or as directed by your healthcare
professional.
Consult your healthcare professional prior to use. Individuals
taking medication should discuss potential interactions with their
healthcare professional. Do not use if tamper seal is damaged.

Supreme CoQ10 combines micro-emulsified coenzyme Q10 (CoQ10) with enzymatically enhanced MaxSimil® fish oil to deliver a highly
absorbable formulation designed to promote optimal cardiovascular health.*
Kaneka CoQ10® (Ubiquinone)
CoQ10 is a fat-soluble compound utilized on a cellular level to generate energy in the form of adenosine triphosphate (ATP) and protect

tissues from the burden of oxidative stress, particularly on the heart. CoQ10 is found in the body primarily in its interchangeable ubiquinone
and ubiquinol forms.*
In general, CoQ10 supports mitochondrial energy production, antioxidant activity, cell membrane stabilization, gene expression and apoptosis,
and neurological and cardiovascular health.[1,2] Levels of CoQ10 in the body can be affected by a number of factors; dietary contribution is
minimal, and serum levels tend to decline with age or can be reduced due to drug-induced depletion.*[3-5]
Synthesis of CoQ10 in the body is regulated by the enzyme HMG-CoA reductase. A variety of factors can inhibit HMG-CoA reductase and
hinder CoQ10 production and availability resulting in a potential increase in oxidative stress and a decrease in energy generation. In the event
of reduced production or drug-induced depletion, supplementation with CoQ10 is recommended to help maintain normal levels in the body.*[6,7]
The contribution of CoQ 10 supplementation to cardiovascular health has been supported in human research studies.[2,6,8-10] A randomized,
double-blind, placebo-controlled study utilizing Kaneka CoQ10 ubiquinone was conducted in a select group of 49 patients. Researchers
observed that supplementation with 100 mg/day successfully restored plasma levels and significantly increased total CoQ10 levels by 127%.*[11]
In the randomized, double-blind, placebo-controlled Q-SYMBIO study, 420 patients were assigned to parallel groups to receive CoQ10 (100
mg three times per day) or placebo. Within three months, researchers observed in the CoQ10-supplemented patients a reduction in N-terminal
pro-B-type natriuretic peptide (NT-proBNP), an important marker of heart health. After two years, patients who were supplemented with CoQ10
had significant cardiovascular improvement overall compared to placebo.*[12]
In addition to the studies above that explored restoring drug-induced plasma CoQ10 production, research into restoring plasma levels that
naturally decline with aging has also been conducted. In a study of older adults (N = 24) supplemented with 300 mg/day of CoQ10 for seven
days prior to cardiac surgery, the CoQ10 content of atrial tissue was significantly increased in those taking the supplement, especially in patients
older than 70 years.*[13]
MaxSimil® Fish Oil Concentrate
The two most well-researched omega-3 fatty acids are the biologically activated oils eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA). EPA plays a role in supporting healthy cardiac and circulatory systems while DHA is an essential structural component of the
central nervous system. In addition to other physiological effects, research has established that omega-3 fatty acids antagonize arachidonic
acid-induced eicosanoid formation. They also help generate resolvins and protectins (EPA and DHA metabolites naturally produced in vivo
through enzymatic conversion of EPA and DHA) to aid the body’s “clean-up” response to the arachidonic acid cascade, and they promote
cardiovascular health.*[14-21]
Supreme CoQ10 features MaxSimil, a novel monoglyceride concentrated fish oil developed using a unique delivery system that enhances
absorption of lipid-based and lipid-soluble nutraceutical and food ingredients. Its patented lipid absorption enhancement technology (PLATform)
is a unique vehicle by which to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically emulsifiers and are, by nature, in a
readily absorbable form, they can bypass the body’s normal fat digestion process. Studies conducted by the manufacturer of MaxSimil provide
promising results that show MaxSimil oil may be better absorbed than other fish oils. Rather than supplying a single molecule or metabolite,
which would mirror the pharmaceutical model, MaxSimil provides all the benefits of EPA and DHA as well as the expected and desirable
benefits of their metabolites. The fish oil is also non-GMO, certified sustainable from Scandinavia, and antibiotic-free.*[22-25]
An unpublished phase 1, double-blind, randomized, crossover, pharmacokinetic study was performed in healthy adults (n = 20) aged between
19 and 71 years who were administered 6 g (containing 1800 mg EPA and 1200 mg DHA) per day of ethyl ester (EE) fish oil or MaxSimil.
Parameters studied were plasma EPA and DHA concentration (as percent of total fatty acids), Cmax, and AUC. Compared to EE EPA+DHA,
the results indicated that at peak concentration, MaxSimil EPA and DHA forms were three times higher, they reached maximum concentration
faster, and maintained their plasma levels longer demonstrating enhanced clinical bioavailability.[25] While there is no conclusive published
evidence at this time, the results from studies conducted by the makers of MaxSimil provide a promising indication of enhanced absorption
rates, and additional peer-reviewed research is warranted.

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.