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Purety Peak Bone Strength 60 packets

Purety Peak Bone Strength 60 packets

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Description

Download Peak Bone Strength Discussion Sheet

Supports Total Bone Health and Strength*
Clinically Tested

 - Provide a Multifaceted Approach to Bone Maintenance and Strength*

- Provide Foundational Bone Support with Choline-Stabilized Orthosilicic Acid (ch-OSA®)*

- Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*

- Provide a Complementary Combination of Micronutrients*

 Peak Bone Strength  is a comprehensive, convenient, and cost-effective dietary supplement that supports healthy bones, cartilage, and ligaments. Each packet provides the following: two capsules containing a combination of microcrystalline hydroxyapatite concentrate (MCHC) and vitamin D3, along with one capsule of choline-stabilized orthosilicic acid (ch-OSA®).*

Bone is composed of a calcium-based mineral complex and an organic material known as collagen. A somewhat flexible and fibrous protein, collagen appears to be a key factor in a bone’s ability to withstand sudden impact. The quantity and health of collagen determines the bone’s “toughness,” while the mineral content determines its strength and stiffness.*

OSAplex contains choline-stabilized orthosilicic acid, a well-absorbed form of silicon that has been clinically tested. Silicon-dependent enzymes link together single chains of amino acids to synthesize collagen fibers. The surfaces of these collagen fibers act as the binding sites for the MCHC. The more surface area available to the MCHC to bind to, the more flexible the bone.*

MCHC, a proprietary, standardized, safe, bovine-sourced bone extract from New Zealand, contains a crystalline calcium and phosphorus matrix in the ideal physiological ratio of 2:1, plus bioactive growth factors and type I collagen. As a source of calcium, MCHC contributes to the production and maintenance of bone structure, a function supported by vitamin D3. Amino acids, glycosaminoglycans, and a broad range of essential trace elements are also present.*

Combining ch-OSA and MCHC with vitamin D3 results in a unique package that addresses quantity and quality of bone, and supports overall bone strength and health.*

Purety Peak Bone Strength is a dietary supplement that provides a multifaceted approach to bone maintenance and strength. It contains a combination of microcrystalline hydroxyapatite concentrate (MCHC) and vitamin D3, along with choline-stabilized orthosilicic acid (ch-OSA®) in each packet. MCHC is a proprietary, standardized, and safe bone extract from New Zealand that contains a crystalline calcium and phosphorus matrix in the ideal physiological ratio of 2:1, plus bioactive growth factors and type I collagen. Vitamin D3 supports the function of calcium in the body, while ch-OSA promotes bone collagen formation, bone mineral density, and bone calcium binding sites. It provides a unique package that addresses the quantity and quality of bone, supports overall bone strength and health, and is clinically tested.

Here are the details about Purety Peak Bone Strength 60 packets:

  • Ingredients:
    • Microcrystalline hydroxyapatite concentrate (MCHC)
    • Vitamin D3
    • Choline-stabilized orthosilicic acid (ch-OSA®)
  • Benefits:
    • Supports bone health and strength
    • Promotes bone collagen formation
    • Increases bone mineral density
    • Increases bone calcium binding sites
    • Provides a complementary combination of micronutrients
  • Dosage:
    • Take 1 packet daily, with or without food.

Overall, Purety Peak Bone Strength 60 packets is a natural supplement that can help to support bone health and strength. It is made with a blend of ingredients that have been shown to be effective in supporting bone health, promoting bone collagen formation, increasing bone mineral density, increasing bone calcium binding sites, and providing a complementary combination of micronutrients.

Supplement Facts

Serving Size: 1 Packet
Servings Per Container: 60

--

Amount Per Serving

% DV

Vitamin D3 (cholecalciferol)

50 mcg (2000 IU)

250%

Calcium (as MCHC)S2

550 mg

42%

Phosphorus (as MCHC)S2

198 mg

16%

MCHCS2

2.2 g

**

Microcrystalline Hydroxyapatite (as MCHC)S2

1.32 g

**

Choline-stabilized orthosilicic acid Capsule

Amount Per Serving

%DV

Choline (as choline-stabilized orthosilicic acid)S1

60 mg

11%

Silicon (as choline-stabilized orthosilicic acid)S1

3 mg

**

** Daily Value (DV) not established.

Other Ingredients

Capsule (hypromellose and water), vegetable stearic acid, vegetable magnesium stearate, medium-chain triglyceride oil, and silica.Microcrystalline cellulose, capsule (hypromellose), and purified water.

S1. Choline-stabilized orthosilicic acid (ch-OSA®) is a registered trademark of and manufactured by
Bio Minerals n.v., Belgium. Produced under US patents 5,922,360; 7,968,528;and 8,771,757.

Directions for Use

Consume the contents of one packet with a meal, one to two times daily, or as directed by your healthcare professional.

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Discussion

Bone health is dependent on a constant supply of micronutrients for maintenance and repair. Instead of adopting a single-nutrient, unbalanced approach to supplementation, Purety Family Medical Clinic utilizes an array of complementary, well-researched nutrients in its Peak Bone Strength line of formulas to build and maintain bone over time.*



Peak Bone Strength is our original formula, and it provides ch-OSA®, MCHC (microcrystalline hydroxyapatite concentrate), and vitamin D3.

ch-OSA® (Choline-Stabilized Orthosilicic Acid)  ch-OSA is a patented, stabilized, readily absorbed, and bioactive form of silicon called orthosilicic acid. Because regular orthosilicic acid is highly unstable, leading it to form polymers, and because the polymers are too large for the human body to absorb, ch-OSA features patented “choline stabilization” technology. This stabilization prevents polymers from forming, ensuring optimal absorption of orthosilicic acid.* 

Decades of research suggest that there is a positive association between dietary silicon and bone mineral density (BMD).[1] The mechanisms of action appear to be silicon’s support of collagen synthesis and stabilization, extracellular matrix mineralization, and connective tissue integrity.[2,3]  Cell-line studies have shown that type I collagen synthesis is stimulated by orthosilicic acid (silicon).[4] Type I collagen is a dense, heavily crosslinked protein that creates an extremely high tensile strength[5] and contributes to bone strength and flexibility. These strong collagen strands are believed to create core-post “binding sites” for calcium and other bone minerals.*[6-8]


In a 12-month clinical trial conducted at St. Thomas’ Hospital in London, women already taking 1000 mg of calcium and 800 IU of vitamin D, to which they added ch-OSA, saw thighbone mineral density at the hip (i.e., femoral neck) increase by 2.00% compared to placebo. This was as a result of an increase in actual bone formation, not just a decrease in loss.[9] Furthermore, the procollagen marker P1NP (procollagen type-1 N-terminal propeptide) increased significantly after 12 months in women who took ch-OSA compared to women in the placebo group. P1NP is known as the most sensitive marker for bone collagen formation and an early marker of bone formation.[9] Animal studies support the human clinical findings for ch-OSA with respect to collagen formation and BMD.*[6,7,10]


Microcrystalline Hydroxyapatite Concentrate (MCHC)
Purety Family Medical Clinic uses standardized, safe, bovine-sourced MCHC (Ossopan) from New Zealand. The OIE-World Organisation for Animal Health has classified New Zealand as a “negligible BSE risk country,” the most favorable official classification a country can be given.[11]  MCHC is manufactured under proprietary processes that meet FDA, USDA, and EU regulatory requirements, and frequent heavy metal assays assure purity. Proprietary techniques preserve the bioactive contents of bone and create a naturally balanced formula because whole-bone extract provides an array of nutrients found in healthy bone: calcium, phosphorus, magnesium, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements. Gentle processing retains the delicate protein matrix and organic factors, and X-ray-diffraction analysis confirms the microcrystalline structure.
The MCHC is assayed for hydroxyproline content and the collagen content is greater than 22% with the majority being type l, the predominant collagen occurring in bone.*

Decades of scientific studies suggest that Ossopan/MCHC supplementation fundamentally supports BMD and bone health.[12-15] A metaanalysis of six controlled studies suggested that hydroxyapatite was significantly more effective than calcium carbonate in supporting bone structure and BMD, and another study favorably compared its absorption to calcium gluconate.*[16,17]



Vitamin D3
Although vitamin D3 (cholecalciferol) is made in the skin when 7-dehydrocholesterol reacts with sunlight, many things affect the degree to which this biosynthesis occurs, including time of day, seasons, location, smog/pollution, clothing, shade of skin (darker skin requires more sun), and sunscreen use. Low-cholesterol diets and certain cholesterol therapies can also affect vitamin D formation. By some estimates, one billion people worldwide have vitamin D deficiency or insufficiency.[18] The body needs vitamin D to absorb calcium, and the importance of vitamin D in skeletal health and bone density is well-established. Without adequate absorption, the body must take calcium from its stores in the skeleton, which weakens existing bone and prevents the formation of strong, new bone. Researchers suggest that vitamin D supplementation may decrease bone turnover and increase BMD.[19] A pooled analysis evaluating 11 randomized, double-blind, placebo-controlled trials supported this analysis. It concluded that vitamin D supplementation (> 800 IU daily) was favorable in maintaining hip and nonvertebral bone integrity in individuals aged 65
and older.*[20]

Although D2 and D3 are similar biochemically, one study demonstrated D3 to be approximately 87% more potent in raising and maintaining serum calcidiol (the body’s storage form) concentrations and in producing two- to threefold greater storage of vitamin D than did equimolar D2.*[21]



Peak Bone Strength MK-7 provides the same ingredients found in Peak Bone Strength (ch-OSA, MCHC, and D3) as well as vitamin K2 as menaquinone-7 (MK-7).

Vitamin K2
MK-7 is a bioactive, bioavailable form of vitamin K2.[22] The biological role of vitamin K in relation to calcium and bone is to help deposit calcium into appropriate areas in the body, such as bones and teeth. Conversely, vitamin K is needed to prevent the accumulation of calcium in other areas, such as in arteries and soft tissues, through vitamin K-dependent carboxylation of Gla proteins. Vitamin K also supports bone integrity by moderating the synthesis of prostaglandin E2 (PGE-2) and interleukin-6 (IL-6) by osteoclasts.[23,24] A three-year study utilizing 180 mcg/d of MK-7 concluded that MK-7 significantly improved vitamin K status, supported bone mineral content and BMD, and favorably supported bone strength and integrity in healthy postmenopausal women.*[25]

Formulated to Exclude

Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms
(GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
Continued

References

1. Jugdaohsingh R. Silicon and bone health. J Nutr Health Aging. 2007 Mar-Apr;11(2):99-110. [PMID: 17435952]

2. Silicon. Natural Medicines. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1096. Accessed March 3, 2016.

3. Martin KR. Silicon: the health benefits of a metalloid. Met Ions Life Sci. 2013;13:451-73. [PMID: 24470100]

4. Reffitt DM, Ogston N, Jugdaohsingh R, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.
Bone. 2003 Feb;32(2):127-35. [PMID: 12633784]

5. Blair HC, Robinson LJ, Huang CL, et al. Calcium and bone disease. Biofactors. 2011 May-Jun;37(3):159-67. [PMID: 21674636]

6. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the
collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997 Feb;56(2):153-65. [PMID: 9164661]

7. Calomme MR, Geusens P, Demeester N, et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized
orthosilicic acid. Calcif Tissue Int. 2006, Apr;78(4): 227-32. [PMID: 16604283]

8. Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength. Osteoporos Int. 2006;17(3):319-36. [PMID: 16341622]

9. Spector TD, Calomme MR, Anderson SH, et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone
formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008 Jun 11;9:85. [PMID: 18547426]

10. Calomme MR, Wijnen P, Sindambiwe JB, et al. Effect of choline-stabilized orthosilicic acid on bone density in chicks. Calcif Tissue Int. 2002, 70:292. Poster presented at: 29th European Symposium on Calcified Tissues; May 25-29, 2002; Zagreb, Croatia. Abstract P-139. http://www.ectsoc.org/zagreb2002/poster3.htm. Accessed April 26, 2016.

11. Bovine Spongiform Encephalopathy (BSE). OIE-World Organization for Animal Health Web site. http://www.oie.int/animal-health-in-the-world/official-disease-status/
bse/list-of-bse-risk-status/. Accessed April 26, 2016.

12. Pelayo I, Haya J, De la Cruz JJ, et al. Raloxifene plus ossein-hydroxyapatite compound versus raloxifene plus calcium carbonate to control bone loss in
postmenopausal women: a randomized trial. Menopause. 2008 Nov-Dec;15(6):1132-38. [PMID: 18791486]

13. Castelo-Branco C, Pons F, Vicente JJ, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J
Reprod Med. 1999 Jul;44(7):601-05. [PMID: 10442322]

14. Albertazzi P, Steel SA, Howarth EM, et al. Comparison of the effects of two different types of calcium supplementation on markers of bone metabolism in a
postmenopausal osteopenic population with low calcium intake: a double-blind placebo-controlled trial. Climacteric. 2004 Mar;7(1):33-40. [PMID: 15259281]

15. Rüegsegger P, Keller A, Dambacher MA. Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females.
Osteoporos Int. 1995 Jan;5(1):30-34. [PMID: 7703621]

16. Castelo-Branco C, Ciria-Recasens M, Cancelo-Hidalgo MJ, et al. Efficacy of ossein-hydroxyapatite complex compared with calcium carbonate to prevent bone loss: a meta-analysis. Menopause. 2009 Sep-Oct;16(5):984-91. [PMID: 19407667]

17. Buclin T, Jacquet AF, Burckhardt P. Intestinal absorption of calcium gluconate and oseine-mineral complex: an evaluation by conventional analyses [in French].
Schweiz Med Wochenschr. 1986 Dec 13;116(50):1780-83. [PMID: 3026039]

18. Tsiaras WG, Weinstock MA. Factors influencing vitamin d status. Acta Derm Venereol. 2011 Mar;91(2):115-24. [PMID: 21384086]

19. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91. [PMID: 21872800]

20. Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012 Jul 5;367(1):40-49.
[PMID: 22762317]

21. Heaney RP, Recker RR, Grote J, et al. Vitamin D3 is more potent than vitamin D2 in humans. J Clin Endocrinol Metab. 2011 Mar;96(3):E447-52. [PMID: 21177785]

22. Schurgers LJ, Teunissen KJ, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
Blood. 2007 Apr 15;109(8):3279-83. [PMID: 17158229]

23. Weber P. Management of osteoporosis: is there a role for vitamin K? Int J Vitam Nutr Res. 1997;67(5):350-56. [PMID: 9350477]

24. Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc. 1997 Nov;56(3):915-37. [PMID: 9483660]

25. Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
Osteoporos Int. 2013 Sep;24(9):2499-507. [PMID: 23525894]

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